NLRP3 Polyclonal Antibody
- Catalog Number : A340131
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Introduction
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
General Information
| Application | WB, ELISA |
|---|---|
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q96P20 |
| Immunogen | Recombinant protein of human NLRP3 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | AGTAVPRL,AII/AVP,Angiotensin/vasopressin receptor AII/AVP like,Angiotensin/vasopressin receptor AII/AVP-like,C1orf7,Caterpiller protein 1.1,CIAS 1,CIAS1,CLR1.1,Cold autoinflammatory syndrome 1,Cold autoinflammatory syndrome 1 protein,Cryopyrin,Familial cold autoinflammatory syndrome,FCAS,FCU,LRR and PYD domains-containing protein 3,Muckle-Wells syndrome,MWS,NACHT,NACHT LRR and PYD containing protein 3,NALP 3,NALP3,NALP3,NLR family pyrin domain containing 3,NLRP3,PYPAF 1,PYPAF1,PYRIN containing APAF1 like protein 1,PYRIN-containing APAF1-like protein 1 |
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