Histone H2B Monoclonal Antibody
- Catalog Number : A330126
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Introduction
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB |
| Clonality | Monoclonal |
| Conjugate | Non-conjugated |
| Uniprot | P33778 |
| Isotype | IgG |
| Immunogen | Synthetic Peptide |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | HIST1H2BA,testis,bA317E16.3,H2B,H2B histone family member U,H2B histone family member U testis specific,H2B histone family,member U,(testis specific),H2B testis,H2B1A,H2BFU,H2BT,HIST1H2BA,Histone 1,H2ba,Histone cluster 1 H2ba,Histone H2B,Histone H2B testis,Histone H2B type 1 A,Histone H2B type 1-A,Histone H2B type 1A,STBP,Testis specific histone H2B,Testis-specific histone H2B,TSH 2B,TSH2B,TSH2B.1 |
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