General Information
| Application | Inhibitor |
|---|
| Description | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Rafand VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
|---|
| Cas NO. | 475207-59-1 |
|---|
| Purity | ≥99% |
|---|---|
| Molecular Weight | 637.03 |
| Formula | C21H16ClF3N4O3.C7H8O3S |
| Solubility |
DMSO : 127 mg/mL Ethanol : Insoluble Water : Insoluble |
|---|
| Alias | Nexavar ; Bay 43-9006 ; Sorafenib |
|---|
| Target / IC50 |
Raf-1 : 6 nM B-Raf : 22 nM B-Raf (V599E) : 38 nM PDGFRβ : 57 nM VEGFR2/Flk : 15 nM |
|---|
| Storage |
Powder : -20°C for 3 years |
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|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.5698 mL | 7.8489 mL | 15.6978 mL | |
| 5 mM | 0.3140 mL | 1.5698 mL | 3.1396 mL | |
| 10 mM | 0.1570 mL | 0.7849 mL | 1.5698 mL | |
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