General Information
| Application | Inhibitor |
|---|
| Description | PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). |
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| Cas NO. | 1210608-43-7 (free-base) |
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| Purity | ≥98% |
|---|---|
| Molecular Weight | 476.92 |
| Formula | C24H23F3N4O.HCl |
| Solubility |
DMSO : 88 mg/mL Ethanol : 88 mg/mL Water : Insoluble |
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| Alias | LGH447 |
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| Target / IC50 |
Pim1 : 6 pM Pim2 : 18 pM Pim3 : 9 pM |
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| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.0968 mL | 10.4839 mL | 20.9679 mL | |
| 5 mM | 0.4194 mL | 2.0968 mL | 4.1936 mL | |
| 10 mM | 0.2097 mL | 1.0484 mL | 2.0968 mL | |
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