General Information
| Application | Inhibitor |
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| Description | GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1. |
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| Cas NO. |
873652-48-3 |
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| Purity | ≥99% |
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| Molecular Weight | 408.32 |
| Formula | C25H34N6O3S |
| Solubility |
DMSO : 99 mg/mL Ethanol : 99 mg/mL Water : 3 mg/mL |
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| Storage |
Powder : -20°C for 3 years |
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| Target / IC50 |
XIAP-BIR2 : 112 nM XIAP-BIR3 : 28 nM MLXBIR3SG : 14 nM cIAP1-BIR3 : 17 nM cIAP2-BIR3 : 43 nM |
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| Alias |
L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)- |
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1 mg |
5 mg |
10 mg |
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|
1 mM |
2.0055 mL | 10.0273 mL | 20.0545 mL | |
| 5 mM | 0.4011 mL | 2.0055 mL | 4.0109 mL | |
| 10 mM | 0.2005 mL | 1.0027 mL | 2.0055 mL | |
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