General Information
| Application | Inhibitor |
|---|
| Cas NO. |
146426-40-6 |
|---|
| Purity | ≥99% |
|---|---|
| Molecular Weight | 401.84 |
| Formula | C21H20ClNO5 |
| Solubility |
DMSO : 15 mg/ml Ethanol : 8 mg/ml H2O : Insoluble |
|---|
| Description | Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. |
|---|
| Target / IC50 |
CDK1 : 30 nM CDK2 : 40 nM CDK4 : 20-40 nM CDK6 : 60 nM |
|---|
| Storage |
Powder : -20°C for 3 years Solvent : -80°C for 2 years |
|---|
|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.4886 mL |
12.4428 mL |
24.8855 mL |
|
|
5 mM |
0.4977 mL |
2.4886 mL |
4.9771 mL |
|
|
10 mM |
0.2489 mL |
1.2443 mL |
2.4886 mL |
|
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