hCG (ABT-HCG) mouse mAb
- Catalog Number : A130240
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Introduction
Specificity：This antibody detects endogenous levels of human hCG. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section.
Background：glycoprotein hormones, alpha polypeptide(CGA) Homo sapiens The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Function：
Similarity: Belongs to the glycoprotein hormones subunit alpha family.,
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
Subcellular Location：Cytoplasmic
Background：glycoprotein hormones, alpha polypeptide(CGA) Homo sapiens The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Function：
Similarity: Belongs to the glycoprotein hormones subunit alpha family.,
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
Subcellular Location：Cytoplasmic
General Information
| Reactivity | Human |
|---|---|
| Application | IHC |
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Non-conjugated |
| Uniprot | P01215 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human hCG |
| Assay principle | IHC-p 1:100-500 |
| Sample type | paraffin section |
| Purity | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Expression region | Pituitary,Placenta |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instruction | -20°C/1 year |
| Research topic | generation of a signal involved in cell-cell signaling, reproductive developmental process, thyroid hormone generation,cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, cell-cell signaling, sex differentiation, gonad development, response to endogenous stimulus, response to hormone stimulus,hormone transport, response to organic substance, regulation of hormone levels, thyroid gland development,gonadotropin secretion, luteinizing hormone secretion, cellu |
| Alias | CGA |
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