anti-HER2 (Ado-trastuzumab emtansine)
- Catalog Number : A510009
- Number : A510009-1mg
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Introduction
Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.
General Information
| Reactivity | Human |
|---|---|
| Application | Functional Assay |
| Host | CHO cells |
| Clonality | Monoclonal |
| Conjugate | Non-conjugated |
| Isotype | Human IgG1 |
| Cas No. | 1018448-65-1 |
| Purity | >95%; < 0.75 EU/mg as determined by the LAL method |
| Molecular Weight | 149 kDa |
| Storage buffer | 0.01 M phosphate buffered saline (PBS) pH 7.2 |
| Storage instruction | This solution is stable for at least 4 weeks when stored at 2-8°C. For long term storage aseptically aliquot and store at –80°C.Avoid repeated freeze/thaw cycles. |
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