Antibody, COVID-19 
, COVID-19 antibody, COVID-19 Neutralizing Antibody
Anti-SARS-CoV-2 S-hIgG1 Neutralizing Antibody
- Catalog Number : A510001
- Number : A510001
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Introduction
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
General Information
| Application | Neutralization |
|---|---|
| Host | Human |
| Conjugate | Non-conjugated |
| Isotype | Human IgG1 |
| Immunogen | 80–120 % compared to the reference sample in an ELISA test |
| Purity | ≥95 % |
| Formula | Liquid, may turn slightly opaque during storage |
| Storage buffer | PBS, pH 7.4 |
| Storage instruction | 24 months from manufacturing at <-20 °C; 1 month, 2 to 8 °C under sterile conditions. |
| Alias | coronavirus s1,coronavirus s2,coronavirus spike,cov spike,ncov RBD,ncov s1,ncov s2,ncov spike,novel coronavirus RBD,novel coronavirus s1,novel coronavirus s2,novel coronavirus spike,RBD,S1,s2,Spike RBD |
Immunoreactivity: 80–120 % compared to the reference sample in an ELISA test.
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