Introduction
Tipifarnib (IND 58359; R115777) is a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib (Zarnestra; IND 58359; R115777) binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, it prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.
General Information
| Cas No. | 192185-72-1 |
|---|---|
| Purity | > 98% |
| Molecular Weight | 489.4 |
| Formula | C27H22Cl2N4O |
| Solubility | DMSO：48.94 mg/mL│ethanol；9.79 mg/mL |
| Storage instruction | 2 years -20°C Powder │ 2 weeks 4°C in DMSO │ 6 months -80°C in DMSO |
| Alias | Zarnestra; IND 58359; R115777; IND-58359; IND58359; R-115777; R 115777 |
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