General Information
| Application | Inhibitor |
|---|
| Description | Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtu2. Phase2 |
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| Cas NO. | 1316214-52-4 |
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| Purity | ≥98% |
|---|---|
| Molecular Weight | 433.5 |
| Formula | C24H27N5O3 |
| Solubility |
DMSO : 86 mg/mL Ethanol : Insoluble Water : Insoluble |
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| Alias | Rocilinostat |
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| Target / IC50 |
HDAC1 : 58 nM HDAC2 : 48 nM HDAC3 : 51 nM HDAC6 : 4.7 nM HDAC8 : 100 nM |
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| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.3068 mL | 11.5340 mL | 23.0681 mL | |
| 5 mM | 0.4614 mL | 2.3068 mL | 4.6136 mL | |
| 10 mM | 0.2307 mL | 1.1534 mL | 2.3068 mL | |
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