General Information
Application | Inhibitor |
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Description | Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. |
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Cas NO. | 1508250-71-2 |
Purity | ≥98% |
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Molecular Weight | 495.02 |
Formula | C26H31ClN6O2 |
Solubility |
DMSO : 99 mg/mL Ethanol : 99 mg/mL Water : Insoluble |
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Alias | EGF816, NVS-816 |
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Target / IC50 |
mutant EGFR : 0.031 μM |
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Storage |
Powder : -20°C for 3 years |
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|
1 mg |
5 mg |
10 mg |
|
1 mM |
2.0201 mL | 10.1006 mL | 20.2012 mL | |
5 mM | 0.4040 mL | 2.0201 mL | 4.0402 mL | |
10 mM | 0.2020 mL | 1.0101 mL | 2.0201 mL |