General Information
| Application | Inhibitor |
|---|
| Description | Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. |
|---|---|
| Cas NO. | 1508250-71-2 |
| Purity | ≥98% |
|---|---|
| Molecular Weight | 495.02 |
| Formula | C26H31ClN6O2 |
| Solubility |
DMSO : 99 mg/mL Ethanol : 99 mg/mL Water : Insoluble |
|---|
| Alias | EGF816, NVS-816 |
|---|
| Target / IC50 |
mutant EGFR : 0.031 μM |
|---|
| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
2.0201 mL | 10.1006 mL | 20.2012 mL | |
| 5 mM | 0.4040 mL | 2.0201 mL | 4.0402 mL | |
| 10 mM | 0.2020 mL | 1.0101 mL | 2.0201 mL | |
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