General Information
| Application | Inhibitor |
|---|
| Description | AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 1/2. |
|---|
| Cas NO. | 1197958-12-5 |
|---|
| Purity | ≥98% |
|---|---|
| Molecular Weight | 529.01 |
| Formula | C26H34ClN6O2P |
| Solubility |
DMSO : 45 mg/mL Ethanol : 106 mg/mL Water : Insoluble |
|---|
| Target / IC50 |
ALK : 0.07 nM EGFR (C797S/del19) : 28.4 nM IGF1R : 32 nM EGFR (del19) : 36.8 nM |
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| Alias | AP-26113; AP 26113 |
|---|
| Storage |
Powder : -20°C for 3 years |
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|
|
1 mg |
5 mg |
10 mg |
|
|
1 mM |
1.8903 mL | 9.4516 mL | 18.9032 mL | |
| 5 mM | 0.3781 mL | 1.8903 mL | 3.7806 mL | |
| 10 mM | 0.1890 mL | 0.9452 mL | 1.8903 mL | |
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