TYK2 Polyclonal Antibody
- Catalog Number : A340694
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Introduction
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.
General Information
| Reactivity | Mouse, Monkey |
|---|---|
| Application | WB, IF, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P29597 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Tyr1054. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | JTK 1,JTK1,Non receptor tyrosine protein kinase 2,Non receptor tyrosine protein kinase TYK2,Non-receptor tyrosine-protein kinase TYK2,OTTHUMP00000232745,OTTHUMP00000232746,OTTHUMP00000232748,Protein Tyrosine Kinase 2,TYK 2,Tyk2,TYK2,Tyrosine kinase 2 |
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