Catenin-α E/N Polyclonal Antibody
- Catalog Number : A340468
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Introduction
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IF, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P35221,P26232 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Catenin-α E/N |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein |
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