Phospho-GSK3 alpha (Ser21) Polyclonal Antibody
- Catalog Number : A340229
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Introduction
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA, IP |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P49840 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human GSK3α around the phosphorylation site of Ser21 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | DKFZp686D0638,Glycogen synthase kinase 3 alpha,Glycogen synthase kinase-3 alpha,GSK 3 alpha,GSK 3A,GSK-3 alpha,Gsk3a,GSK3A,GSK3alpha,Serine/threonine protein kinase GSK3A |
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