Antibody, Antibody Sampler Kit

Apoptosis Antibody Sampler Kit

  • Catalog Number : AK0118
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Introduction

Apoptosis is a regulated physiological process leading to cell death. Caspases, a family of cysteine acid proteases, are central regulators of apoptosis. Initiator caspases (including 8, 9, 10 and 12) are closely coupled to proapoptotic signals. Once activated, these caspases cleave and activate downstream effector caspases (including 3, 6 and 7), which in turn cleave cytoskeletal and nuclear proteins like PARP, α-fodrin, DFF and lamin A, and induce apoptosis. Cytochrome c released from mitochondria is coupled to the activation of caspase-9, a key initiator caspase. Proapoptotic stimuli include the FasL, TNF-α, DNA damage and ER stress. Fas and TNFR activate caspases 8 and 10, DNA damage leads to the activation of caspase-9 and ER stress leads to the calcium-mediated activation of caspase-12. The inhibitor of apoptosis protein (IAP) family includes XIAP and survivin and functions by binding and inhibiting several caspases. Smac/Diablo, a mitochondrial protein, is released into the cytosol upon mitochondrial stress and competes with caspases for binding of IAPs. The interaction of Smac/Diablo with IAPs relieves the inhibitory effects of the IAPs on caspases.

General Information

Reactivity Human, Mouse, Rabbit
Application WB, ELISA
Host Rabbit
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic Regulation of Apoptosis

Cat No.

Product name

Quantity

Applications

Reactivity

Host

A340389

Cleaved-CASP3 p17 (D175) Polyclonal Antibody

20μL

WB, IHC, ELISA

Human, Mouse, Rat

Rabbit

A340458

CASP3 Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat

Rabbit

A340740

PARP1 Polyclonal Antibody

20μL

WB, ELISA

Human, Mouse, Rat

Rabbit

A340398

Cleaved-PARP1 (D214) Polyclonal Antibody

20μL

WB, ELISA

Human, Mouse

Rabbit

A340394

Cleaved-CASP9 p35 (D315) Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human

Rabbit

A340466

CASP9 Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat

Rabbit

A340391

Cleaved-CASP7 p20 (D198) Polyclonal Antibody

20μL

WB, IHC, ELISA

Human, Mouse

Rabbit

A340462

CASP7 Polyclonal Antibody

20μL

WB, IHC, ELISA

Human

Rabbit

A1013s

Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)

120μL

WB, ELISA

Rabbit

Goat

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